The segmented volumes of cerebrum in first episode schizophrenia with auditory hallucinations in Korea

초록

Objective : Many study on the brain structure in schizophrenic psychopathology was performed. In this study, the volumes of cerebral and cerebellar regions were measured in patients with auditory hallucination and without auditory hallucination in first episode schizophrenia by brain magnetic resonance imaging. Method: Brain magnetic resonance images were obtained in 17 patients with auditory hallucination and 8 patients without auditory hallucination in first episode schaizophrenia. Cerebral and Cerebellar regions were segmented to gray and white fractions using algorithm for semi-automated fussy tissue segmentation. They were defined using the semi-automated Talairach atlas-based parcellation method. Results: Patients with auditory hallucination showed a larger temporal, frontal, temporal white matter, frontal gray matter, temporal gray matter volume than patients without auditory hallucination. Conclusion: These findings suggest that auditory hallucination in schizophrenia may have neuropathological abnormalities in temporal, frontal, temporal white matter, frontal gray matter, temporal gray matter volume.