Activity and selectivity studies of 4-phenylpiperazine derivatives on D2-like dopamine receptors using 3D-QSAR and docking methods

초록

The D2-like dopamine receptors are associated with neuropathological disorder such as schizophrenia, drug addiction and Parkinson's disease. In this study, we identify activity and selectivity factors of D2-like receptor with 4-phenylpiperazine derivatives using computational method such as 3D-QSAR, molecular docking and homology modelling.