Combination of peptides with biological, organic, and inorganic materials for synergistically enhanced diagnostics and therapeutics

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초록

Armed with the useful properties of small molecules and proteins, peptides hold the potential to be utilized in almost all biomedical research fields. However, the clinical application of peptides has been limited due to their intrinsic drawbacks, such as poor plasma stability and low target binding affinity. The conjugation of peptides to biological, organic (nonbiological), and inorganic materials has recently emerged as a promising strategy to address these problems. Hence, in this article, we provide an overview of the successful outcomes of using peptide-bio/organic/inorganic conjugates in various biomedical applications, including the diagnosis and treatment of diseases.

키워드

drug deliverymolecular imagingpeptide conjugatespeptide inhibitorsMRI CONTRAST AGENTSRGD-BASED STRATEGIESPHOTOTHERMAL THERAPYHALF-LIFEIN-VIVOCONJUGATED EXENDIN-4PROTEIN INTERACTIONSCOMPUTED-TOMOGRAPHYMOLECULAR-WEIGHTCANCER-THERAPY
제목
Combination of peptides with biological, organic, and inorganic materials for synergistically enhanced diagnostics and therapeutics
저자
Kim, Joo-YoungLee, Jae YunPark, Ha YeonKim, HyunjiKang, Jeon HyeongKim, Hyun JinJeong, Woo-jin
DOI
10.1002/pep2.24233
발행일
2022-05
유형
Review
저널명
Peptide Science
114
3