Combination of peptides with biological, organic, and inorganic materials for synergistically enhanced diagnostics and therapeutics

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7

초록

Armed with the useful properties of small molecules and proteins, peptides hold the potential to be utilized in almost all biomedical research fields. However, the clinical application of peptides has been limited due to their intrinsic drawbacks, such as poor plasma stability and low target binding affinity. The conjugation of peptides to biological, organic (nonbiological), and inorganic materials has recently emerged as a promising strategy to address these problems. Hence, in this article, we provide an overview of the successful outcomes of using peptide-bio/organic/inorganic conjugates in various biomedical applications, including the diagnosis and treatment of diseases.

키워드

drug delivery; molecular imaging; peptide conjugates; peptide inhibitors; MRI CONTRAST AGENTS; RGD-BASED STRATEGIES; PHOTOTHERMAL THERAPY; HALF-LIFE; IN-VIVO; CONJUGATED EXENDIN-4; PROTEIN INTERACTIONS; COMPUTED-TOMOGRAPHY; MOLECULAR-WEIGHT; CANCER-THERAPY
제목
Combination of peptides with biological, organic, and inorganic materials for synergistically enhanced diagnostics and therapeutics
저자
Kim, Joo-Young; Lee, Jae Yun; Park, Ha Yeon; Kim, Hyunji; Kang, Jeon Hyeong; Kim, Hyun Jin; Jeong, Woo-Jin
DOI
10.1002/pep2.24233
발행일
2022-05
유형
Review
저널명
Peptide Science
권
114
호
3