Attenuation of Psoriasis Symptoms Following Treatment with C-phycocyanin from Spirulina Maxima in a Mouse Model

초록

Psoriasis is a chronic autoimmune disease caused by an abnormal proliferation of keratinocytes in the epidermis. The efficacy of C-Phycocyanin, a photosynthetic pigment isolated from Spirulina Maxima, was assessed via histological examinations, and anti-inflammatory properties were investigated in mouse models of imiquimod-induced psoriasis (BALB/C-nu and BALB/C). C-phycocyanin lowered epidermal thickening, as well as immune cell clustering in the dermis. Furthermore, C-phycocyanin modulated the levels of inflammatory cytokines (tumor necrosis factor-alpha, interleukin [IL]-6, cyclooxygenase-2, IL-1b) in the BALB/C-nu mouse model and psoriasis-related cytokines (IL-17a, interferon-gamma, calcitonin gene-related peptide) in BALB/c mice. We show that C-phycocyanin could be developed as a natural pharmaceutical against psoriasis.

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