Synthesis of pyrazoline derivatives from N-silyl enamine and nitrile imine

초록

Enamines can be utilized for the synthesis of amines, amidines, and other nitrogen containing functional groups, showing a variety of applicability for organic synthesis and medicinal chemistry. Our previous studies have focused on the synthesis of cyclic amidines using organic azides with enamine intermediates from the borane catalyzed hydrosilylation of isoquinolines and quinolines. This study is about construction of pyrazoline ring by using [3 + 2] cycloaddition of the nitrile imine with the N-silyl enamine from the readily available N-heteroarenes.