Three-day Regimen of Fluorouracil and Cisplatin Combination Chemotherapy for Metastatic or Recurrent Uterine Cervical Cancer

초록

Background: The five-day infusion of FP(5-FU, cisplatin) combination therapy is one of the most popular regimen in advanced cervical cancer. It has a 50-60% response rate. There are variable types in the FP regimen. But long day infusion type of FP needs more longer hospitalization and endurance of patients. This study was designed to assess the therapeutic effect and toxicities of three days regimen of FP combination chemotherapy instead of five days regimen for disseminated or recurrent cervical cancer. Results: Thirty five patients were evaluable for response with a median follow up of 21.5 months. The median age of patients was 53 years. Response rate was 45.7% (4 CR and 12 PR). Median overall survival was 30 months. Toxicities in grade 3 or more included neutropenia in 16% with 4 febrile episodes throughout a total 232 cycles. It did not appear alopecia and GI trouble in grade 3 or more. Conclusion: These results revealed that the toxicity of 3 day regimen of 5-FU and cisplatin is acceptable and the efficacy comparable to that of 5 day regimen