Mitogen-activated protein kinase phosphatase 1 (MKP-1) in obesity-associated atherosclerosis: a redox-regulated master controller of monocyte function and macrophage phenotype.

초록

Mitogen-activated protein kinase (MAPK) pathways play key roles in the activation of monocytes in response to a variety of triggers, including growth factors, chemokines, pathogens and environmental cues. These signaling pathways are also central to the regulation of macrophage function and phenotypic plasticity. MAPK phosphatase 1 (MKP-1) has emerged as a key redox-regulated counter-regulator of MAPK signaling in monocytes and macrophages. MKP-1 deficiency in monocytes and macrophages leads to the dysregulation of monocyte adhesion and migration, and gives rise to dysfunctional, proatherogenic monocyte-derived macrophages. Here we review the current state of knowledge on this dual-specificity MAPK phosphatase and its role in monocyte and macrophage biology and cardiovascular diseases.