Application of mini-pig as a type 2 diabetic mellitus animal model

초록

Diabetes is one of the rapid growing diseases at present and considered one of the serious diseases to overcome for human life. Among the animal models used for the drug efficacy test, mini-pig model is going to rapidly upload because of many similarities with human, particularly concerning the pharmacokinetic of compounds after subcutaneous administration, the structure and function of the gastrointestinal tract, the morphology of the pancreas, and overall metabolic status. Based on these various advantages, we try to develop Type II diabetic mellitus animal model with mini-pig and test its application on the surgical therapy method. We set 8 male mini-pigs for the induction of moderate insulin deficient model with Nicotinamide/Streptozotocin treatment. Among them, we tested 4 pigs for surgical try such as gastric bypass and the rest as a disease control. For the evaluation of Type II diabetic incidence and recovery, we checked blood glucose level, OGTT as well as immunohistochemistry of pancreatic tissue. Based on these results, we want to suggest that the animal model developed can be used for efficacy test of surgical try as well as its development.