자궁경부 원추절체후 HPV검사를 해야하는 기간에 관하여

초록

Background: The statistic data for HPV disappearance after conization are not shown so far. To know when is the optimal timing for HPV test after conization, we performed a serial test of HPV after conization. Methods: Between 1997 to 2004, Large Loop Excisions of the Transformation Zone (LLETZ) were done for conization to women with cervical pathology at Inha University Hospital. The Pap and HPV typing were planned tobe done every 3 months at least for 2 years. Every HPV typing was done by HPV oligonucleotide microarray (biomedlab Co., Seould, South Korea). Results: For 8 years, 120 LLETZ were enrolled in this study. There were 8 cases of no neoplasm, 9 cases of CIN 1, 17 cases of CIN 2, 74 cases of adenocarcinoma in situ. HPV DNA before LLETZ was found about 85% and subtype16 was the most common type among the patients with cervical lesion (40.8%) by HPV oligonucleotide microarray. After LLETTZ, 190 HPV typing were done through 1,307 total months (average, 6.9 months/typing). 95 (79.2%) cases had negative result after LLETZ, and 25 (20.8%) of negative results of HPV typing came out in 6 months after LLETZ among the group in which the HPV typing results turned out negative ultimately. Conclusion: Our data suggested HPV DNA testing should be done after 6 months of LLETZ, as about 80% of the group that were destined for negative results were turned out in 6 months