CD4+CD28- 세포의 활성 및 관용을 조절하는 T 세포 costimulation 과 그 경로(초청강연)

초록

CD28- cells constitute approximately one third to one half of the circulating CD8+ and CD4-CD8- T cells(8,9). In contrast, CD4+CD28- T cells are present only in a subset of normal individuals but are expanded in patients with RA(24,36). The size of the CD28-CD4+ and CD28-CD8+ subsets are increased in the peripheral blood of HIV positive patients(37). Several studies have shown that the subsets of CD28- T cells contain oligoclonal T cell populations(24, 38, 39). Although these oligoclonal T cell populations are not necessarily associated with disease and can occur in normal individuals, they can be more pronounced in patients with autoimmune disease such as RA and may contribute to the disease manifestations(40-42). At least some of these CD28- T cell clones respond to autoantigens(24,43). Therefore, we propose that a CD28 independent costimulatory pathway is essential in the regulation of human CD28- T cells and contributes to the emergence of oligoclonal T cell population in disease.