When should human papillomavirus (HPV) testing be done after conization?

초록

Objectives: To know when human papillomavirus (HPV) testing should be done after conization. Methods: Between 1997 to 2004, Large Loop Excisions of the Transformation Zone (LLETZ) were done for conization to women with cervical pathology at Inha University Hospital. The Pap and HPV typing were done before LLETZ. After conizations, HPV typing were planned to be done every 3 months at least for 2 years. Every HPV typing was done by HPV oligonucleotide microarray (Biomedlab Co., Seoul, South Korea). Results: For 8 years, 120 LLETZ were enrolled in this study. There were 8 cases of no neoplasm, 9 cases of CIN 1, 17 cases of CIN 2, 74 cases of CIN 3, 10 cases of microinvasive cervix cancer, and 2 cases of adenocarcinoma in situ. HPV DNA before LLETZ was found about 85.0% and subtype 16 was the most common type among the patients with cervical lesion (40.8%) by HPV oligonucleotide microarray. After LLETZ, 190 HPV typing were done through 1,307 total months (average, 6.9 months/typing). 95 (79.2%) cases had negative results after LLETZ, and 25 (20.8%) cases had positive results. Our data showed that about 80% of negative results of HPV typing came out in 6 months after LLETZ among the group in which the HPV tying results turned out negative ultimately. Conclusions: Our data suggested HPV DNA testing should be done after 6 months of LLETZ, as about 80% of the group that were destined for negative results were turned out in 6 months.