대장 직장암에서 림프절 전이 및 예후에 영향을 미치는 인자에 관한 연구

초록

Background/Aims: This study was carried out to evaluate prognostic significance of clinicopathological features in colorectal cancer. Methods: 413 patients who underwent curative resection of colorectal cancer from June of 1996 to December of 2000 were studied about clinicopathological factors and difference of survival rate. Results: The numbers of lymph node metastasis were significantly related to age, depth of invasion, histologic differentiation, tumor size, lymphovascular invasion, perineural invasion, and preoperative serum CEA level. In the univariate analysis for 366 patients, depth of invasion (p=0.0017), histologic differentiation (p=0.0069), lymph node metastasis (p=0.0000), lymphovascular invasion (p=0.0001), perineural invasion (p=0.0008), and preoperative serum CEA level (p=0.0005) were found as significant prognostic factors. The histologic differentiation was the same between the primary lesion and the metastatic lymph node in 90.7% of all cases. Capsular invasion was found at 92 cases (53.5%), there was no significant difference of survival rate compared with non-capsular invasion group (p=0.0510). Conclusions: Depth of invasion and lymph node metastasis were important prognostic variables for colorectal cancer, the number of lymph node metastasis was important prognostic factor. Further follow-up is needed to determine the role of the various clinical and pathological factors in colorectal cancer prognosis.