<i>Angelica gigas</i> Nakai 뿌리배양에 의한 decursin 유도체 생산 증진을 위한 연구

초록

Production of decursinol angelate, a new potential anticancer agent, in <i>Angelica gigas</i> Nakai root culture was increased by treatment of H₂O₂, and various polysaccharides such as CM-β-cyclodextrin, glucan, CM-β-chitin, yeast extract and pectin. One mmole H₂O₂ enhanced the production of decursinol angelate. However, higher concentrations of H₂O₂ were founded to be toxic for root growth whereas specific productivity of decursinol angelate was increased at high concentrations of H₂O₂. In the case of polysaccharide elicitors, CM-β-chitin was the most effective for enhanced production of secondary metabolite in <i>A. gigas</i> Nakai root culture.