Bcl-2 and p53 immunoreativity associated with tumor response to radiotherapy in cervical carcinoma

초록

cervical carcinoma is common cancer among woman in Korea. The one of effective treatment method of high stage cervical cancer is the radiotherapy, but high percentages of the tumor show no response in radiotherapy. The factors which effect radiotherapy can be stage, tumor size, lymph node status, etc. The aim of this study is to define the role of pretreatment expression of the p53 protein and the bcl-2 protein and their relationship to tumor response to radiotherapy in cervical carcinoma. A totla 33 patients were evaluated. These patients were divided into two groups; group1 which are disese free(n=18) and group2 which have residual or recurrent disease(n=15). P53 and bcl-2 protein expression was determined by immunohistochmistry. The intensity of p53 protein was graded as 0, 1, 2, 3 and the number of p53 protein positive cells was counted under the high power field. The intensity and positive cell numbers of bcl-2 protein were low, so it was only divided into two groups; bcl-2 positive group and negative group. There was no statistical correlation immunoreactivity of bcl-2 and p53 protein and response to radiotherapy. The correlation between the stages and radiotherapy was also none. These results indicate that bcl-2 and p53 may not have a important role in the radiotherapy of cervical cancer. However, the case number of this study is small, it needs to be confirmed in a large series.