Selectivity of Gold Catalysis with Alkenes and Furan Activation

초록

The construction of C-C bond by gold-catalysis has been an important subject for the synthetic chemist. The complexation of C-C unsaturated bond to a gold-catalysis center is significantly important, which provides a basis for olefin transformations. The mechanisms of hydroarylation of α,β-unsaturated alkenes by furans were investigated by DFT calculation. Our results indicated that the reaction favors the direct auration of the furan firstly, which clarified the ambiguity of direct auration of the furan or the activation of the alkene proposed by Hashmi in experiment. The results were consistent with the previously study on the priority of gold catalyst complexation on the unsaturated system.