Photoactivable liposomes for controlled delivery: Recent progress and design considerations

초록

Recent strides in drug delivery have aimed at precise control over therapeutic agent release and targeting. Liposomes, lipid-based vesicles, have stood out for their capacity to encapsulate diverse agents. While their structural features offer biocompatibility and stability, the inability to provide on-demand drug release limits their efficacy. Addressing these limitations, photoactivable liposomes, leveraging light as a trigger, offer a compelling solution. This strategy surpasses established controlled systems, providing spatiotemporal precision and non-invasive external triggering. Furthermore, the versatility of photoactivation, achieved through the manipulation of light-responsive components, enables meticulous control over release kinetics. While extant reviews predominantly concentrate on release strategies and materials, this paper takes a novel approach by spotlighting recent advancements in categorized photoactivable liposomes. Moreover, drawing from contemporary illustrations, the article accentuates design considerations that encompass physicochemical properties and light-related constituents. These insights collectively contribute to the evolution of sophisticated drug delivery systems.

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