한국인에서 쇼그렌 증후군의 선별 및 추적검사로서 건빵 용해 검사의 개발

초록

OBJECTIVE - To investigate the usefulness of the Hardtack test to screen the Sj?ren's syndrome compared with non-stimulated whole salivary flow (NSWSF) and Schirmer-1 test. METHODS - Fifty patients with RA and other connective tissue disease who had complained sicca symptoms (7 males and 43 females) and twenty healthy participant, were undergone the Hardtack test, NSWSF, and Schirmer-1 test. The Hardtrack test were compared with NSWSF and Schirmer-1 test for the screening of Sj?ren's syndrome. And the relationship between the tests were evaluated. RESULTS - 1) The time of dissolution of the hardtack was 88.7sec (Max : 136, Min : 44) in healthy group, and 321 sec (Ma : 900, Min : 92) in patient group (p<0.001). 2) NSWSF was 0.6 ml/min (Max : 1.32, Min : 0.14) in healthy group, and 0.28 ml/min (Max : 0.8, Min : 0.01) in patient group (p<0.001). 3) The lacrimal flow in Schirmer-1 test was 22.0 mm (Max : 30, Min : 8) in healthy groups and 5.26 mm (Max : 21, Min : 0) in patient group (p<0.001). 4) The correlation coefficient between the hardtack test and NSWSF was - 0.56 (p<0.001). The correlation coefficient between the hardtack test and Schirmer-1 test was -0.51 (p<0.001). NSWSF was correlated with Shirmer-1 test but not significantly (r=0.254, p=0.075).