영문제목 Seum Concentration of TNF-a Related Apoptosis Inducing Ligand (TRAIL) Is Decreased in Patients with Rheumatoid Arthritis (RA)

초록

Background: TNF-a related apoptosis inducing ligand (TRAIL) is a member of TNF superfamily that promotes apoptosis by binding to the transmembrane receptors. The effects of TRAIL in RA are debatable. Objective: This study was performed to evaluate the effects of TRAIL on RA by measuring serum concentration of TRAIL in patients with RA and assessing relationships between the TRAIL concentration and various clinical parameters of RA. Methods: 105 patients with RA, 34 patients with osteoarthritis, and 35 age- and gender-matched healthy controls were enrolled.