Design and Synthesis of 1-Phenyl Barbituric Acid Containing N-Substituted Indole derivatives as a Non-Competitive Inhibitor against PTP1B Enzyme

초록

As most intracellular signaling takes place via cascades of phosphorylation and dephosphorylation of tyrosine, protein tyrosine phosphatases have emerged as new and promising target for type 2 diabetes and obesity.