Olanzapine administration may induce inflammatory reactions with nitric oxide-triggered lipid abnormality

초록

Background Chronic treatment with new atypical antipsychotic drug, olanzapine (OLZ) in Schizophrenia patients is associated with the incidence of the adverse effects like hypertriglyceri- demia, weight gain and obesity-induced diabetes. Nitric oxide (NO) overproduced by inducible NO synthase in the inflammatory reaction may trigger these lipid abnormalities. Hypothesis & Procedures We hypothesized that OLZ-induced adverse effects might be accompanied by a low-grade systemic inflammatory reaction. The serum levels of major Inflammatory markers like NO and prostaglandin E2 (PGE2) and lipid markers were determined in animal models treated with OLZ. Aim This study is to identify causative mechanism of lipid abnormality, an important adverse effect of atypical antipsychotic drug OLZ.