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Potential Novel Genes for Late-Onset Alzheimer's Disease in East-Asian Descent Identified by APOE-Stratified Genome-Wide Association Study
- Kang, Sarang;
- Gim, Jungsoo;
- Lee, Jiwoon;
- Gunasekaran, Tamil Iniyan;
- Choi, Kyu Yeong;
- ... Choi, Seong Hye;
- 외 17명
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31초록
The present study reports two novel genome-wide significant loci for late-onset Alzheimer's disease (LOAD) identified from APOE epsilon 4 non-carrier subjects of East Asian origin. A genome-wide association study of Alzheimer's disease was performed in 2,291 Korean seniors in the discovery phase, from the Gwangju Alzheimer's and Related Dementias (GARD) cohort study. The study was replicated in a Japanese cohort of 1,956 subjects that suggested two novel susceptible SNPs in two genes: PRIG1 and CACNA1A. This study demonstrates that the discovery of AD-associated variants is feasible in non-European ethnic groups using samples comprising fewer subjects from the more homogeneous genetic background.
키워드
Alzheimer's disease; APOE; genome-wide association study; late-onset Alzheimer's disease; stratified genome analysis; SLOWER COGNITIVE DECLINE; METAANALYSIS; EXPRESSION; REVEALS; CALCIUM; SORL1; RISK
- 제목
- Potential Novel Genes for Late-Onset Alzheimer's Disease in East-Asian Descent Identified by APOE-Stratified Genome-Wide Association Study
- 저자
- Kang, Sarang; Gim, Jungsoo; Lee, Jiwoon; Gunasekaran, Tamil Iniyan; Choi, Kyu Yeong; Lee, Jang Jae; Seo, Eun Hyun; Ko, Pan-Woo; Chung, Ji Yeon; Choi, Seong-Min; Lee, Young Min; Jeong, Jee Hyang; Park, Kyung Won; Song, Min Kyung; Lee, Ho-Won; Kim, Ki Woong; Choi, Seong Hye; Lee, Dong Young; Kim, Sang Yun; Kim, Hoowon; Kim, Byeong C.; Ikeuchi, Takeshi; Lee, Kun Ho
- 발행일
- 2021
- 유형
- Article
- 권
- 82
- 호
- 4
- 페이지
- 1451 ~ 1460