Effects of the mutations of the p53 tumor suppressor gene and the K-ras gene on clinical manifestation in NSCLC

초록

58 patients were enrolled who had lived for more than 1 month without any complication after curative resection. The paraffin-embedded lung tissues were used to investigate the mutations of p53 and K-ras genes. p53 gene mutation had no clinical or prognostic significance because of scattered locatons and diverse modes of mutation in contrast to K-ras gene mutation, which had a significantly negative effect on the prognosis of NSCLC. p53 and K-ras gene mutations were apparently independent genetic alterations which played different roles in the clinical manifestation and prognosis of NSCLC.