Activity and Selectivity Studies of 4-Phenylpiperazine Derivatives on D2-like Dopamine Receptors using 3D-QSAR and Docking Methods

초록

The D2-like dopamine receptors are associated with neuropathological disorder such as schizophrenia, drug addiction and Parkinson’s disease. It is difficult to design the subtype-specific compounds to reduce side-effects because of high homology among subtype receptors. In this study, we identify activity and selectivity factors of D2-like receptor with 4-phenylpiperazine derivatives using computational method such as 3D-quantitative structure activity relationship (3D-QSAR), molecular docking and homology modeling.