Characterization of the unique function of self aggregation and disulfide dimerization of the peptdie with membrane permeability

초록

We identified an active fragment from tenecin 1, an insect defensin protein. Interestingly, the active fragment that had unique primary structure containing three cys residues did not show antimicrobial activity dependent on the presence of DTT. To understand the mode of the active fragment and the function of DTT in the biological action, we investigated interactions of the peptide with vesicles resembling of the vesicle inversely dependenet on the cocenctration of DTT.