Synthetic Approaches to Pumiliotoxin C

초록

A disubstituted cyclohexanecarboxylate was prepared streoselectively via a base induced β-elinimation of 7-oxabicyclo[2.2.1]heptanes which was prepared by a Diels-Alder reaction followed by catalytic hydrogenation. Pumiliotoxin C was attemped to be prepared by β-elinimation. The amino moiety was introduced by a nucleophilic substitution of the resulting hydroxy group.