Nucleophilic Substitution Reaction of N-Methyl a-Chloroacetanilide with Benzylamine in Dimethyl sulfoxide

초록

The kinetic and mechanism of the aminolysis of α-chloroacetanilide [YC6H4NHC(=O)CH2CL] with benzylamines (AC6H4CH2NH2) were investigated in dimethyl sulfoxide at 55℃. The kinetic results show that the studied reactions proceed by the step-wise mechanism ; ρx=-0.68~-0.47, βx=0.87~0.61, and ρx=0.67~0.54 values show that bond formation is greater than bond breaking in the transition state. This results were also supported by ρxy value. Bond-formation step is the rate determining step.