Utilization of the N-silyl enamines for the synthesis of novel N-heterocycles and functional molecules

초록

N-silyl enamine is a versatile but fragile functional group in organic chemistry. Due to the instability of the N?Si bond, the endocyclic N-silyl enamines had never been utilized for the organic synthesis until recent year. However, our group recently developed a synthetic methodology to synthesize cyclic amidines via in-situ utilization of the endocyclic N-silyl enamines from dearomatization of the N-heteroarenes. The substrate scope of this strategy covered the quinolines, isoquinolines, and pyridines. In the same vein, this seminar will cover our ongoing studies on the reactivity of N-silyl enamines with the activated acyl azides and the azomethine imines. An unexpected reaction pathway of the linear N,N-disilyl enamines will follow.