Plasma lipid levels change with alkaline phosphatase concentration during normal pregnancy.

초록

To investigate the relationship between the change in blood lipid levels and alkaline phosphatase concentrations during pregnancy, we measured blood lipid profiles and alkaline phosphatase concentrations in 546 apparently healthy pregnant, postpartum and nonpregnant subjects. The triglyceride and total cholesterol levels increased gradually as pregnancy proceeded, reaching maximal values in the third trimester, returned to nonpregnancy level 20 weeks after delivery. The concentration of alkaline phosphatase was 2.1-fold higher in the late third trimester than in the first trimester, while triglyceride level was 2.3-fold higher in the same period. Compared to the each maximal value, alkaline phosphatase concentration was 45.2% lower and triglyceride level was 47.1% lower 12 weeks after delivery, respectively. The alkaline phosphatase concentration correlated significantly with the total cholesterol lefel (r=0.68, p<0.01) and the triglyceride concentration (r-0.71, p<0.01). In conclusion, blood triglyceride and total cholesterol levels change with alkaline phosphatse concentrations during normal pregnancy.