6-Membered cyclic amidine synthesis from N-heterocyclesvia dearomatization strategy

초록

Since the cyclic amidine exists in a variety of natural and pharmacological molecules, various synthetic strategies have been studied. According to our previous study, the electron density of the azide critically affect to the reactivity of the enamine intermediate and the azide. Although the benzoylazide and enamine intermediates have shown low reactivity, it was possible to improve the reactivity by attaching functional groups to the benzoyl azide. Herein, we report synthesis of various cyclic acyl amidines from acyl azides.