Neuromuscular Junction Disorder with Progressive Cerebellar Dysfunction in A Lung Cancer Patient

초록

Introduction Paraneoplastic neurologic syndromes (PNS) can affect the central nervous system (eg, paraneoplastic cerebellar degeneration [PCD]) and the neuromuscular junction (eg, Lambert-Eaton myasthenia syndrome [LEMS] and myasthenia gravis [MG]). A small percentage of patients with small cell lung cancer (SCLC) have a PNS, of which the most frequent is LEMS. The symptoms of PNS could arise before the diagnosis of SCLC. And we need to pay attention to these patients. The screening recommendation for the patient with motor weakness due to neuromuscular junction disorder (LEMS type) would be repeated cancer screening tests including CT or positron emission tomography (PET) scans. Early diagnosis can advance initiation of anti-tumor therapy and thereby improve survival. We experienced a patient, who presented initially LEMS, MG and PCD, was finally diagnosed with PNS by SCLC.