일개 대학병원 신규 의료종사자의 예방접종대상 감염병 항체 양성률과 관련 요인 조사, 2019-2023

초록

Background: Seroprevalence among health care workers is important in planning vaccination programs. We aimed to confirm the antibody positivity rates for vaccine-preventable diseases and the factors affecting the rates. Methods: We performed a retrospective descriptive analysis using the health screening data of 1,948 new employees at a 901-bed hospital in Incheon from 2019 to 2023. For the antibodypositive group, we performed a multivariate analysis according to age, sex, and occupation. Results: The median age of the 1,948 health care workers was 25 years, and 80.2% were female. Antibody positivity rates for hepatitis B virus, hepatitis A virus, varicella-zoster virus, measles virus, and rubella virus were 85.5%, 65.1%, 91.9%, 89.2%, and 83.7%, respectively. The adjusted odds ratios (ORs) for doctors, other health care workers, and office workers/technicians were 0.592, 0.306, and 0.077 for hepatitis B, and 0.578, 0.408, and 0.285 for hepatitis A, respectively, when compared with values for nurses. The adjusted ORs for hepatitis A were 2.025 and 14.794 among those aged 40-49 years and 50 years or older, respectively, compared with those aged 20-29 years. The adjusted ORs for those aged 30-39 years, 40-49 years, and 50 or more years were 2.366, 4.071, and 9.725 for varicella-zoster virus, and 3.599, 2.586, and 6.129 for measles virus, respectively, compared with those aged 20-29 years. The adjusted OR for rubella virus was 2.3 for those aged 30-39 years compared with those aged 20-29 years. Conclusion: We confirmed differences in antibody positivity rates for each infectious disease according to age and occupation. These findings can be used for efficient employee vaccination planning in health care facilities.

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