Photobiomodulation Therapy in Mice with Chronic Cerebral Hypoperfusion Using Application-Specific Near-Infrared Light-Emitting Diode System

초록

The effective delivery of light energy from the light source to the subject is essential for an increase of therapeutic usefulness in the photobiomodulation therapy. Here, we demonstrate the application-specific near-infrared (NIR) LED therapy system applicable to the mouse for brain repair. The proposed NIR LED therapy system especially employ the curved-shape NIR LED module and the LED dimmer for optimal transfer of the light energy to the mouse brain. The therapeutic effects are evaluated in mice with chronic cerebral hypoperfusion by the positron emission tomographic scans. In the near future, we would like to quantitatively validate the therapeutic effect of our proposed NIR LED therapy system on mice with brain injury and apply it to a human brain. © 2019, The Korean Institute of Electrical and Electronic Material Engineers.

키워드