MELATONIN DOWN REGULATES NUCLEAR ERYTHROID 2-RELATED FACTOR 2 AND NUCLEAR FACTOR-KAPPAB DURING PREVENTION OF OXIDATIVE LIVER INJURY IN A DIMETHYLNITROSAMINE MODEL

초록

INTRODUCTlON: Melatonin has potent hepatoprotective effects as an anti-oxidant. However, the signaling pathway of melatonin in the induction of anti-oxidant enzymes against acute liver iujury is not fully understood.