The relationship of VEGF expression, histologic grade, and proteinuria in the IgA Nephropathy

초록

Vascular endothelial growth factor is a highly selective mitogen in vascular endothelila cells and increses microvascular permeability. It might be involved in the development of proteinuria. In IgA nephropathy, the fidings asoociated with poor prognosis are following; heavy proteinuria, hypertension, persistently decresed GFR, incresed serum creatinin, severe histologic grade, glomerular sclerosis, interstitial nephritis or fibropsis, endocapillary proliferation, and numerous circumferential cresecnts. The aim of this study is to evaluate relatioship between histologic grade and degree of expression of the VEGF. The relationship between histologic grade and degree of proteinuria was also evaluated. Seventy patients of IgA nephropathy were selected. Immunohistochemistry was performed on the paraffin-embedded tissue using the antiVEGF antibody. The grading of intensity of VEGF expression was done; 0, 1, 2, and 3. The histologic grading was donr accoding to WHO and Haas classification. There was no relatioship between histologic grading and VEGF expression. However, both histologic gradings were correlated with the 24hour urine protein level. The glomerular VEGF expression was also correlated with the 24 hour urine protein level. The results suggest that VEGF expression is related to the proteinuria, and it is not related hitologic grade. However, considering tht histolgic grade is correlated with the protienuria, VEGF may play a role in the progression of IgA nephropathy.