마늘가루, 콩단백질 및 타우린의 갱년기고지혈증 동물모델에서 혈중지질에 미치는 영향

초록

The purpose of this study was to investigate the effects of garlic, soy protein and taurine on blood lipid profiles in postmenopausal hyperlipidemic model rats. Seventy-two female Sprague-Dawley rats weighing 200g were fed a commercial diet for one week. All rats were ovariectomized and then were randomly assigned to eight groups (high fat diet group; HFD group, 2% garlic powder group; GP group, taurine group; TR group, soy protein group; SP group, 2% garlic powder+taurine group; GP+TR group, 2% garlic powder+soy protein group; GP+SP group, taurine+soy protein group; TR+SP group, 2% garlic powder+taurine+soy protein group; GP+TR+SP group). After 8 weeks of feeding these experimental diets, the rats were sacrificed. Liver, adipose tissue, gastricnemus and psoas weight were measured. Plasma triglyceride, total cholesterol and HDL-cholesterol concentration were analyzed by enzymatic procedures using commercial kits with UV/Vis spectrophotometer at 546nm, 500nm and 500nm, respectively. The statistical analysis was conducted using the SPSS 10.0 program. Mean and standard deviation were calculated for all variables and analyzed by analysis of one-way ANOVA. Relative liver weight of GP+TR and GP+TR+SP groups were significantly lower than the rest groups (p<0.05). Adipose tissue weight around ovary of HFD group was the highest and that of GP+TR+SP group was the lowest. Gastricnemus and psoas muscle weight in GP, SP and GP+TR+SP groups were significantly higher than the rest groups (p<0.05). Plasma triglyceride(TG) level in all groups were significantly lower than HFD group (p<0.05). Especially, plasma TG level in GP+TR+SP group was the lowest compared to the rest groups.