Assessment of Bone Marrow Involvement in Extranodal NK/T-Cell Lymphoma: Positron Emission Tomography versus Bone Marrow Biopsy, and the Significance of Minimal Involvement by EBV plus Cells (KROG 18-09)

초록

Purpose This study aims to investigate the diagnostic significance of positron emission tomography/computed tomography (PET/ CT) in assessing bone marrow (BM) involvement through a comparison of PET/CT findings with BM biopsy in extranodal natural killer /T -cell lymphoma. Materials and Methods The medical records of 193 patients were retrospectively reviewed. Patients were categorized as having early -stage (PET -ES) or advanced -stage (PET -AS) disease based on PET/CT results. The BM involvement was classified into three groups according to BM biopsy: gross BM involvement, minimal BM involvement (defined as the presence of a limited number of Epstein -Barr virus-positive cells in BM), and no involvement. Calculations of the accuracy of PET/CT in detecting BM involvement and analysis of the clinical outcomes (progression -free survival [PFS] and overall survival [OS]) according to the BM biopsy status were performed. Results PET/CT exhibited a sensitivity of 64.7% and a specificity of 96.0% in detecting gross BM involvement. For detecting any (both gross and minimal) BM involvement, the sensitivity was 30.4%, while the specificity was 99.0%. Only one patient (0.7%) demonstrated gross BM involvement among the PET -ES group. Survival outcomes of the PET -ES group with minimal BM involvement (3 -year PFS, 55.6%; OS, 77.0%) were closer to those of the PET -ES group with no BM involvement (3 -year PFS, 62.2%; OS, 80.6%) than to those of the PET -AS group (3 -year PFS, 20.1%; OS, 29.9%). Conclusion PET/CT exhibits high specificity, but moderate and low sensitivity in detecting gross and minimal BM involvement, respectively. The clinical significance of minimal BM involvement for patients in the PET -ES group may be limited.

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