Effect of Taurine Supplementation on Lipid Peroxidation, Activities of Defense Enzymes and Membrance Stability During Rat Hepatocarcinogenesis

초록

The purpose of this study was to determine the effects of taurine supplmentation on the hepatic lipid peroxidation, activities of defense enzymes and membrane stability during rat hepatocarcinogenesis.Hepatocarcinogenesis was induced by Solt & Farber modification. Lipid peroxide contents of carcinogen treated group which was not supplemented with taurine were lower than those of control group. This might be that peroxide is decreased because of the activation of detoxifying enzyme. Glutathione S-transferase(GST) activities of carcinogen treated groups were significantly(p<0.05) increased compared to those of control group. The GST activities of group supplemented with taurine before treatment of carcinogen and during the all period of experiment were only less increased. In carcinogen treated groups, glutathione peroxidase(GPx) activities of groups supplemented with taurine were higher than those of nonsupplemented group. By carcinogen treatment, glucose 6-phosphatase(G6Pase) activities, index of membrane stability were decreased, but in carcinogen treated groups supplemented with taurine,they were less decreased. These results suggest that taurine supplementation seems to inhibit lipid peroxidation, to change the activities of defense enzymes and to prevent to membrane disintegration during chemically induced hepatocarcinogenesis.