Differential expressions of collagen type I and III in the proximal urethra of diabetic rat with aging

초록

Hypothesis/ aims of study It is well known that increased bladder outlet resistance is usually secondary to functional or anatomical obstruction. Previous study has demonstrated that increased urethral resistance was much more prominent in diabetic rats than controls, and that the increased resistance might be resulted from functional obstruction related to urethral nitric oxide synthase containing nerve fibers in part. To ascertain the role of anatomical obstruction other than functional obstruction in diabetes, we characterized the distribution and expression of collagen Type I and II in urethral tissues of diabetic rats comparing to those of controls and explored how they are altered with aging.