Synthetic Anion Transporters as Endoplasmic Reticulum (ER) Stress Inducers

Aslam, Adil S.; Fuwad, Ahmed; Ryu, Hyunil; Selvaraj, Baskar; Song, Jae-Won; Kim, Dae Won; Kim, Sun Min; Lee, Jae Wook; Jeon, Tae-Joon; Cho, Dong-Gyu

doi:10.1021/acs.orglett.9b02823

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Synthetic Anion Transporters as Endoplasmic Reticulum (ER) Stress Inducers

Aslam, Adil S.;
Fuwad, Ahmed;
Ryu, Hyunil;
Selvaraj, Baskar;
Song, Jae-Won;
... Kim, Sun Min;
... Jeon, Tae-Joon;
... Cho, Dong-Gyu;
외 2명

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7

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SCOPUS

7

초록

Cl--ion transporters (2a-2h) were synthesized based on the binding motifs of prodigiosin. Transporter 2e clearly displays Cl--ion transportation activity across both model and live cell membranes. Furthermore, 2e can disrupt Ca2+ homeostasis and increase the intracellular concentration of Ca2+ in the DLD-1 cell. This disruption can lead to Caspase-dependent apoptosis supported by CHOP expression (a marker of ER stress) and the appearance of the cleaved forms of Caspase 3 and PARP.

키워드

CELL-DEATH; APOPTOSIS; BINDING; CALCIUM

제목: Synthetic Anion Transporters as Endoplasmic Reticulum (ER) Stress Inducers

저자: Aslam, Adil S.; Fuwad, Ahmed; Ryu, Hyunil; Selvaraj, Baskar; Song, Jae-Won; Kim, Dae Won; Kim, Sun Min; Lee, Jae Wook; Jeon, Tae-Joon; Cho, Dong-Gyu

DOI: 10.1021/acs.orglett.9b02823

발행일: 2019-10-04

유형: Article

저널명: Organic Letters

권: 21

호: 19

페이지: 7828 ~ 7832