Synthesis, Biological Activity and Receptor-Based 3D QSAR Study of 3'-N-Substitued-N-debenzoylpaclitaxel Analogues

초록

A series of the 3’-N-substituted-N-debenzoylpaclitaxel analogues were synthesized and investigated for their 3D QSAR by using CoMFA analysis. The QSAR model obtained from receptor(microtubule)-paclitaxel binding structure displays an excellent predictive power to forecast the biological activity of new 3’-N-substituted-N-debenzoylpaclitaxel analogues as well as the ability to explain the activity of the known paclitaxel analogues.