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Synthesis of Pyrazolines via (3+2) Cycloaddition of Nitrile Imines and N-Silyl Enamines
- Yun, Sooyeon;
- Cao, Vinh Do;
- Shin, Sooah;
- Ahn, Byungin;
- Joung, Seewon
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0초록
The synthesis of tricyclic fused pyrazolines from N-silyl enamines and nitrile imines is presented. N-Silyl enamines are an emerging class of enamines that can be used as free enamine surrogates. The N-silyl enamines, prepared from readily available isoquinolines, underwent (3+2) cycloaddition with a wide range of nitrile imines to form the corresponding pyrazolines in moderate to good yields. This cascade protocol entailed the in situ utilization of both N-silyl enamine and nitrile imine intermediates.
키워드
N -silyl enamines; B(C6F5)(3); (3+2) cycloaddition; pyrazolines; nitrile imines; SITU GENERATED 1,2-DIAZA-1,3-DIENES; FORMAL 4+1 CYCLOADDITION; 1,3-DIPOLAR CYCLOADDITION; ENANTIOSELECTIVE SYNTHESIS; ACCESS; DIHYDROPYRAZOLES; (3+2)-CYCLOADDITION; DIARYLNITRILIMINES; STEREOCHEMISTRY; ANNULATION
- 제목
- Synthesis of Pyrazolines via (3+2) Cycloaddition of Nitrile Imines and N-Silyl Enamines
- 저자
- Yun, Sooyeon; Cao, Vinh Do; Shin, Sooah; Ahn, Byungin; Joung, Seewon
- 발행일
- 2025-07
- 유형
- Article
- 저널명
- Synthesis
- 권
- 57
- 호
- 13
- 페이지
- 2091 ~ 2100