Guidelines for the Management of Patients with Alopecia Areata in Korea: Part II Systemic Treatment

초록

Background: Alopecia areata (AA) is a chronic disease with an unpredictable course and can have a severe psychological impact on an individual.Objective: To provide evidence and consensus-based statements regarding the treatment of patients with AA in Korea.Methods: We searched for relevant studies from inception to May 2021 regarding the sys-temic treatment of AA. Evidence-based recommendations were also prepared. The evidence for each statement was graded and classified according to the strength of the recommenda-tions. Hair experts from the Korean Hair Research Society (KHRS) voted on the statement, and an agreement of 75% or greater was considered as having reached consensus.Results: Current evidence supports the efficacy of systemic corticosteroids, oral cyclospo-rine monotherapy or combination with systemic corticosteroids, and oral Janus kinase inhibitors in severe AA patients. Systemic steroids may be considered for pediatric patients with severe AA. A consensus was achieved in three out of nine (33.3%), and one out of three (33.3%) statements pertaining to systemic treatment in adult and pediatric AA, respectively.Conclusion: The present study produced up-to-date, evidence-based treatment guidelines for AA associated with the consensus obtained by experts based on the Korean healthcare system.

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