한국인 집단에서 flavin-containing monooxygenase 효소의 FMO3/Lys158 와 FMO3/Gly308 대립인자의 연관유전

초록

Flavin-containing monooxygenase (FMOs) are a family of enzymes involved in metabolism of many clinical used drugs, plant alkaroids, and endogenous compounds. Among FMO isozymes, FMO3 is the major enzyme present in human liver and genetic polymorphism of FMO3 is an important concern in chemotherapy. Thus, FMO3 activities detected in 219 Korean volunteers were correlated with FMO3 genotypes involving 2 common mutant alleles (Glu158Lys and Glu308Gly). These 2 mutant alleles had same frequencies (18.95% for Lys158 and 18.26% for Gly308) and showed clear evidence of linkage. Distribution of FMO3 genotypes determined for each mutation had almost identical frequencies for both mutation sites. Genetic linkage of these 2 common FMO3 gene mutations affects hepatic FMO3 activity in Korean population and influences clinical effects of drugs metabolized by FMO.