Dudleya brittonii Extracts reduced the inflammation of digestive-related disease in animal models

초록

Background: Dudleya brittonii is a succulent plant in the Crassulacease family. It is native to Baja California and Mexico. The leaves of it grow in a basal rosette and are covered with a dusty, chalky, mealy white epicuticular “wax”. The wax has the highest measured ultraviolet reflectivity of any plant. Its potential as a natural extract for medicine, functional food and cosmetic still remains except cancer and anti-oxidant. In the present study we have investigated its role on anti-inflammation in digestive-related animal disease models. Methods: We divided the animals group as following: (1) vehicle control, (2) disease control, (3) 10-3 Dudleya brittonii extracts, (4) 10-3 Dudleya brittonii extracts, (5) positive drug control (gastritis model only). To make gastritis model, indomethacin was given at 30 minutes after Dudleya brittonii extracts administration. 25 mg/kg indomethacin was given to all rats (n=10) by oral gavage in 3% sodium bicarbonate. Seven hours after, the entire rats were sacrificed and confirmed gastrointestinal erosions and ulcers, and then verified further using histological analysis. To make colitis model, 6-8 weeks mice (n=10) was given 2% DSS in distilled water ad-libitum during 7days following replaced regular drinking water for 1day. Mice were daily checked the body weight, bleeding and diarrhea for DAI index. At the autopsy, the rectum was photographed, measured the length and then further progressed the Swiss roll for histological analysis. Conclusions: Our data suggests that Dudleya brittonii extracts functions the decreasing effect on the inflammation of digestive-related disease such as gastritis and colitis.