소변 NAG와 IgA 신증과의 연관성

초록

Tubulointersyitial lesions play apivotal role in the progression of renal diseases including priamary glomerulopathies. The NAG is a lysosomal enzyme abundant in proximal tubular segments. It has been a useful marker to monitor tubular damage in patients with nephrotic syndrome and glomerulonephritis. In the present study, urine NAG activity in the patient of Ig A nephropathy has been compared with changes in the glomerular and tubular morphology and clonical parameters to evaluate the role of urine NAG in IgA Nephropathy. In 39 pateients with primary IgA nephropathy, urinary NAG was measures by colorimetric method. The histologic and clinical parameters were evaluated. The urine NAG level was correlated with some clinical parameters such as 24 urine protein, serumalbumin, protein and cholesterol level. TIG was also correlated with Haas subclassification, glomerular grade, urinary protein, serum BUN, Cr, albumin and protein. These results suggest that urine NAG excretion is probably considered as a reliable marker of the tubular damage in the IGA nephropathy. As TIG was correlated with renal dysfunctin and urine NAG, urine NAG also can be a useful progression marker of IgA nephropathy.