Recrystallization of Cephalosporin Antibiotics with Supercritical Fluids

초록

Cephalosporin Antibiotics was crystallized by using an Aerosol Solvent Extraction System (ASES) with supercritical CO2, where the particle size and morphology was investigated according to pressure, concentration, and solvent. The yield of particles that were collected in the separated membrane filter was about 80%. The particles were analyzed by a Scanning Electron Microscopy (SEM), which showed that the size of primary particle was measured to be 100~200 nm and the morphology is similar to spherical type. The secondary particle size was about 300~600 nm as a result of primary particle agglomeration.