Chryseobacterium arthrosphaeraeventriculitis A case report

초록

Introduction: Chryseobacterium arthrosphaerae is a gram-negative bacteria, known for its intrinsic multidrug resistance, which can lead to treatment difficulties. Patient concerns: A 56-year-old male had an indwelling external ventricular drainage catheter for 6 months and had been frequently treated with antibiotics for nosocomial infections. He showed cerebrospinal fluid pleocytosis and an abrupt fever during hospitalization. Diagnosis: He was diagnosed as a ventriculitis caused byChryseobacterium arthrosphaerae (C arthrosphaerae). Intervention: Initially, we used ciprofloxacin as the backbone in combination with minocycline (and rifampin). However, fever and pleocytosis persisted, and improvement was slow. We then switched the minocycline and rifampin regiment to trimethoprim/sulfamethoxazole. Following this switch of antibiotics, the patient's pleocytosis rapidly improved, allowing the replacement of his external ventricular drainage catheters.C arthrospharaewas no longer growing in cerebrospinal fluid and he was recovered from ventriculitis. Outcomes: The patient remains alive without any incidence ofC arthrosphaeraerecurrence. Conclusion: We propose trimethoprim/sulfamethoxazole alone or in combination with ciprofloxacin to be good candidates for the treatment of ventriculitis byC arthrosphaerae.

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